| 发明名称 |
.BETA.-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HIV INFECTION |
| 摘要 |
Compounds and pharmaceutical compositions active againt HIV are provided, as is a method for the treatment of hepatitis B virus infection in humans and other host animals is provided comprising administering an effective amount of a .beta.-L-(2' or 3'-azido)-2',3'-dideoxy-5-fluorocytosine of formulae (I) a nd (II) wherein R is H, acyl, monophosphate, diphosphate, or triphosphate, or a stabilized phosphate derivative (to form a stabilized nucleotide prodrug), a nd R' is H, acyl, or alkyl.
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| 申请公布号 |
CA2348948(A1) |
申请公布日期 |
2000.05.11 |
| 申请号 |
CA19992348948 |
申请日期 |
1999.11.05 |
| 申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;EMORY UNIVERSITY;THE UNIVERSITY OF ALABAMA AT BIRMINGHAM (UAB) RESEARCH FOUNDATION |
发明人 |
GOSSELIN, GILLES;SOMMADOSSI, JEAN-PIERRE;SCHINAZI, RAYMOND F.;IMBACH, JEAN-LOUIS |
| 分类号 |
C07H19/06;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61P31/18;C07H;(IPC1-7):A61K31/706 |
主分类号 |
C07H19/06 |
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