| 摘要 |
<p>Compounds represented by general formula (I) or their salts, having beta 3 -adrenoceptor agonism and being efficacious when employed in drugs for treating and preventing diabetes, obesity, hyperlipemia, etc. wherein R represents hydrogen or methyl; R<1> represents hydrogen, halogeno, hydroxy, benzyloxy, amino or hydroxymethyl; R<2> represents hydrogen, hydroxymethyl, NHR<3>, SO2NR<4>R<4>', or nitro (wherein R<3> represents hydrogen, methyl, SO2R<5>, formyl or CONHR<6>'; R<5> represents lower alkyl, benzyl or NR<4>R<4>'; R<4> and R<4>' may be the same or different and each represents hydrogen, lower alkyl or benzyl; and R<6>' represents hydrogen or lower alkyl); R<6> represents hydrogen or lower alkyl; n is 1 or 2; X represents secondary nitrogen, oxygen or sulfur; and when n is 1, then one of R<7> and R<8> represents hydrogen while another represents hydrogen, amino, acetylamino or hydroxy, or when n is 2, then R<8> represents hydrogen while R<7> represents hydrogen, amino, acetylamino or hydroxy. <CHEM></p> |
