LIPOSOME-ENTRAPPED TOPOISOMERASE INHIBITORS

摘要

A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining aqueous liposome compartment, and being composed of a vesicle-formi ng lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 .mu.mole drug per .mu.mo le lipid.