摘要 |
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at leat one alpha 2-receptor agonist from the group consisting of clonidine; dexmedetomidine; oxymetazonline; (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoro-methanesulfoanilide; 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline; AGN 191103; AGN 192172; 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (UK14304); 5,6,7,8-tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine (BHT920); 6-ethyl-5,6,7,8-tetrahydro-4H-oxaazolo[4,5-d]azepin-2-amine; and 5,6-dihydroxyl-1,2,3,4-tetrahydro-1-naphyl-imidazoline, and optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration like a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a DOLLAR (g)m-opioid agonist. The solution is applied by continous irrigation of a wound during a surgical procedure for preemptive inhibition of pain.
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申请人 |
OMEROS MEDICAL SYSTEMS, INC.;DEMOPULOS, GREGORY, A.;PALMER, PAMELA, P.;HERZ, JEFFREY, M. |
发明人 |
DEMOPULOS, GREGORY, A.;PALMER, PAMELA, P.;HERZ, JEFFREY, M. |