3',5'-cyclic phosphate compounds and methods thereof

摘要

The invention relates to a compound of formula (I) Wherein: B is adenine, guanine or hypoxanthine Z is hydrogen or a negative charge R is -[CH2CH(R1)-O]n-R2, -CH2CH2X, in which R1 is hydrogen or (C1-6) alkyl R2 is hydrogen or (C1-6) alkyl n is a number from 1 to 6 X is OH, F, NR3R4 R3 and R4 are independently from each other hydrogen or (C1-6) alkyl and to methods of enzymatically treating these compounds with biocatalysts having cyclic phosphodiesterase activity.