| 摘要 |
FIELD: chemistry of amino acids, pharmacy. SUBSTANCE: invention describes a novel GLP-1-molecular complex consisting of bivalent metal cation associated and able to the combined precipitation with compound of the formula: R1- -X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Tyr-Leu-Y-Gly-Gln-Ala- -Ala-Lys-Z-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-R2 where R1 is taken among the group including L-histidine, deamino-histidine, 2-amino-histidine, beta-hydroxy-histidine, homo-histidine, alpha-fluoromethyl-histidine and alpha-methyl-histidine; X is taken among the group including Ala, Gly, Val, Thr, Ile and alpha-methyl-Ala; Y is taken among the group including Glu, Gln, Ala, Thr, Ser and Gly; Z is taken among the group including Glu, Gln, Ala, Thr, Ser and Gly; R2 is taken among the group including NH2 and Gly-OH under condition that the indicated compound has isoelectric point at the range from about 6,0 to about 9,0 and under condition that if R1 means His, X means Ala, Y means Glu and Z means Glu then R2 must be NH2 at molar ratio = (0.1-3): 1. It can be used for enhanced expression of insulin in islet - beta-cells of mammalian pancreas and for treatment of mammals with prematurity-onset diabetes mellitus. Invention describes pharmaceutical composition and method of complex preparing also. EFFECT: improved method of preparing, valuable properties. 12 cl, 2 tbl, 2 ex
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