| 摘要 |
<p>The present invention relates to methods of preventing or treating neurodegenerative diseases by administering an antagonist or inhibitor of p25. In particular, the invention relates to methods of preventing or treating a neurodegenerative disease by administering a calpain antagonist or inhibitor, or a cation antagonist or inhibitor, which reduces the truncation or conversion of p35 to p25. It also relates to p.35 and antibodies directed to p.25 and cdk 5. It relates to methods of inhibiting p25/cdk association, cdk 5 deregulation and phosphorylation of tan. Methods of assessing neurodegeneratives diseases using p 25 are provided.</p> |
