发明名称 |
METHOD FOR THE TREATMENT OF CHEMONUCLEOLYSIS |
摘要 |
The invention relates to a method of treatment for a mammal in need of chemonucleolysis. The method comprising the administration of an effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme and an effective amount of a growth factor effective in promoting the synthesis of a matrix component. The proteoglycan-degrading enzyme is preferably chondroitinase. The growth factor is preferably osteogenic protein. The proteoglycan-degrading enzyme and the growth factor are preferably administered simultaneously.
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申请公布号 |
CA2346375(A1) |
申请公布日期 |
2000.04.13 |
申请号 |
CA19992346375 |
申请日期 |
1999.07.30 |
申请人 |
RUSH-PRESBYTERIAN-ST. LUKE'S MEDICAL CENTER |
发明人 |
SAMPATH, KUBER T.;AN, HOWARD;THONAR, EUGENE J-M.A.;MASUDA, KOICHI |
分类号 |
A61K38/22;A61K38/18;A61K38/46;A61K38/51;A61L27/00;A61L27/22;A61P19/04;C07K14/51;(IPC1-7):C12N5/00;A61K38/43 |
主分类号 |
A61K38/22 |
代理机构 |
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地址 |
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