发明名称 |
METHODS FOR DETERMINING WHETHER A COMPOUND IS CAPABLE OF INHIBITING THE INTERACTION OF A PEPTIDE WITH RAGE |
摘要 |
The present invention provides a method for determining whether a compound i s capable of inhibiting the interaction of a peptide with a receptor for advanced glycation end product (RAGE), which comprises: (a) admixing: (i) th e peptide, wherein amino groups of the peptide are inactivated by derivitization, (ii) RAGE or a fragment thereof, and (iii) the compound; (b) determining the amount of the peptide bound to RAGE or the fragment thereof, and (c) comparing the amount of bound peptide determined in step (b) with th e amount determined when the peptide is admixed with RAGE or a fragment thereo f in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the peptide with RAGE or a fragment thereof, wherein a reduction in the amount of binding in the presence of the compound indicates that the compound is capable of inhibiting the interactio n.
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申请公布号 |
CA2346339(A1) |
申请公布日期 |
2000.04.13 |
申请号 |
CA19992346339 |
申请日期 |
1999.10.05 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
STERN, DAVID;SCHMIDT, ANN MARIE |
分类号 |
G01N33/50;A61K9/12;A61K9/127;A61K9/50;A61K31/472;A61K31/49;A61K45/00;A61P3/00;A61P3/04;A61P3/10;A61P13/12;A61P29/00;A61P37/06;C07K14/705;C12N5/10;C12Q1/02;C12Q1/68;G01N33/15;G01N33/566;G01N33/68;(IPC1-7):C07K14/705;C07K17/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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