Taxoids, preparation thereof and pharmaceutical compositions containing same

摘要

Novel taxoids of the formula (I) shown, the preparation thereof and pharmaceutical compositions containing same, are disclosed. In the formula, Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl, furoyl or thenoyl radical or a radical R2-O-CO- where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, naphthyl or aromatic heterocyclic radical; or R4 is a hydrogen atom, R6 and R7 together form a ketone function, and R and R5 together form a bond; or R4 is a hydrogen atom or a hydroxy radical or an alkoxy, alkenyloxy, optionally substituted alkynyloxy, alkanoyloxy, aroyloxy, alkenoyloxy, alkynoyloxy, cycloalkanoyloxy, alkoxyacetyl, alkylthioacetyl, alkyloxycarbonyloxy, cycloalkyloxy, cycloalkenyloxy, carbamoyloxy, alkylcarbamoyloxy or dialkylcarbamoyloxy radical; R5 is a hydrogen atom, or R4 and R5 together form a ketone function, R6 is a hydrogen atom, and R and R7 together form a bond. The products of formula (I), wherein Z is a radical of general formula (II), are said to have remarkable antitumoral and antileukemic properties.