| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound which is an antagonistic drug for excitable amino acid receptor antagonist drugs, especially selective antagonistic drugs against non-NDM receptors and useful for curing cerebral nerve cell lesion. SOLUTION: This invention relates to a 6,7-asymmetric disubstituted quinoxalinecarboxylic acid derivative expressed by formula I (Q is a halogen, a lower alkyl or the like; R1 is an aralkyl, phenyl, naphthyl, a 5- or 6-membered heterocycle or the like; R2 is hydroxy, a lower alkoxy or the like; R is nitro, trifluoromethyl, amono or the like) and its addition salt, e.g. 7-(3- [(4- carboxyphenyl)aminocarbonylamino]methyl}pyrrol-1-yl)-3,4-dihydro-3-oxo-6- trifluoromethylquinoxaline-2-carboxylic acid. The compound of formula I in which R1 is H is obtained by reacting a compound of formula II (R12 is a lower alkyl or the like) at 20-120 deg.C for 0.5-72 hours using a suitable acid.
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