| 发明名称 |
TARGETED ALPHAVIRUS AND ALPHAVIRAL VECTORS |
| 摘要 |
The present invention provides a recombinant alphavirus comprising at least one epiviral nonalphaviral sequence, which (i) is present in the E1, E2 or E3 glycoprotein as an insertion or as a replacement of one or more amino acid residues and which (ii) directly and selectively binds to a region on a target cell-specific, surface receptor. The present invention also provides the nucleic acids related to said alphavirus, and methods to treat cancer in a mammal using the alphavirus and related nucleic acids.
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| 申请公布号 |
WO0011201(A1) |
申请公布日期 |
2000.03.02 |
| 申请号 |
WO1999US17345 |
申请日期 |
1999.07.30 |
| 申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;DROPULIC, BORO;DROPULIC, LESIA;HARDWICK, J., MARIE |
发明人 |
DROPULIC, BORO;DROPULIC, LESIA;HARDWICK, J., MARIE |
| 分类号 |
G01N33/48;A61K35/76;A61K38/00;A61K48/00;A61P35/00;C07K14/18;C12N7/00;C12N15/09;C12N15/40;C12N15/86;C12Q1/02;C12R1/92;(IPC1-7):C12N15/86;C12N7/01;A61K39/12;C12Q1/70 |
主分类号 |
G01N33/48 |
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