RADICICOL DERIVATIVES WITH ANTITYROSINE KINASE ACTIVITY AND USE THEREOF

摘要

Radicicol derivatives of formula (I) and their salts are new. R1, R2 = H, alkanoyl, alkenoyl, t-butyl diphenylsilyl or t-butyl dimethyl silyl; R3 = YR5, COR13 or optionally substituted aryl; Y = optionally substituted alkylene; R5 = CONR6R7, CO2R12 or optionally substituted aryl, pyridyl, pyridonyl, pyrrolidinyl, uracil, piperidyl, piperidone, pyrrolidonyl, morpholino, morpholinyl, piperazinyl, thiomorpholino or dioxalaryl; R6 = H or R7; R7 = OH, NR8R9 or optionally substituted alkyl, lower cycloalkyl, alkenyl, lower alkoxy, aryl or heterocyclyl; R8, R9 = H or optionally substituted alkyl, lower cycloalkyl, aryl, heterocyclyl, alkanoyl, aroyl, heterocyclylcarbonyl or aryl-carbamoyl or NR7 = optionally substituted heterocyclyl or NR6R7 = optionally substituted heterocyclyl; R12 = substituted lower alkyl or optionally substituted higher alkyl, lower cycloalkyl, alkenyl, aryl or heterocyclyl; R13 = H, NR14R15 or optionally substituted alkyl, aryl or lower alkoxy; R14, R15 = H or optionally substituted alkyl, aryl or pyridyl or NR4R13 = heterocyclyl; X = halo or XR4= bond; R4 = H, alkanoyl, alkenoyl or SOZ; Z = a group of formula (i): X' = halo; W = O or NOR3.