Improvements to strains of streptomyces through the use of biosynthetic genes oftylosine

摘要

The invention relates to a process based on the use of genes of the biosynthetic cluster of tylosine to increase the production of tylosine in S. fradiae. The invention discloses (I) a method for isolating a DNA fragment of S.fradiae which contains 11 genes, 10 of which belong to the cluster of biosynthetic genes of tylosine and (II) the expression of said genes in the microorganism producing the tylosine S. fradiae, as well as in other related microorganisms (Streptomyces spp.) resulting in an increase of the production of tylosine in the first case and in the production of new hybrid antibiotics in the second case.