| 摘要 |
PURPOSE: A process for manufacturing nano-granule that is sensitive to temperature and pH by mixing alkyl acrylamide and N,N-dimethylaminoethylmethacrylate and adding a reaction initiator is provided which gives a simple manufacturing method of nano-granule with a uniform size. CONSTITUTION: Alkyl acrylamide and N,N-dimethylaminoethylmethacrylate are melted in a mixed solvent of water and hydrophilic organic solvent in a volume ratio of 9:1-7:3(preferably 9:1) to give a monomer solution, which is added with a reaction initiator and left at about 50-70°C for 10-20 hr(preferably 15), and filtrated. For an example, N,N-dimethylaminoethylmethacrylate is melted in a mixed solvent of water and ethanol in a volume ratio of 7:3 to give 5 weight% of monomer solution, One hundred weight% of monomer solution is mixed with 0.3 weight% of N,N-azobisisobutyronitryl, left at 60°C for 15 hr, and freeze-dehydrated to give a nano granule. As an amount of ethylacrylamide increases, a diameter of nano-granule becomes short.
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