发明名称 |
TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS AND PEPTIDES |
摘要 |
The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains thr ee or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Morever, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.
|
申请公布号 |
CA2337688(A1) |
申请公布日期 |
2000.02.03 |
申请号 |
CA19992337688 |
申请日期 |
1999.07.23 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
FRIDKIS-HARELI, MASHA;TEITELBAUM, DVORA;AHARONI, RINA;STROMINGER, JACK L.;SELA, MICHAEL;ARNON, RUTH |
分类号 |
A61K38/00;A61K38/16;A61K39/00;A61L27/22;C07K5/11;C07K7/06;C07K7/08;C07K14/00;(IPC1-7):C07K7/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|