发明名称 |
Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk |
摘要 |
ulphaminoheparosansulphates obtainable from the Escherichia coli K5 polysaccharide by deacetilation and the subsequent sulfation with the sulphuric anhydride/trimethylamine adduct carried out at 0 ‹C, for times ranging from 0.25 to 2 hours and using a reactant/polysaccharide ratio (SO3 equivalents/available OH groups equivalents) equal to 5 have been found having high anti-metastatic activity and low anticoagulant activity.
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申请公布号 |
NZ334566(A) |
申请公布日期 |
2000.01.28 |
申请号 |
NZ19970334566 |
申请日期 |
1997.08.28 |
申请人 |
ISTITUTO SCIENTIFICO DI CHIMICA E BIOCHIMICA G RONZONI |
发明人 |
NAGGI, ANNAMARIA;TORRI, GIANGIACOMO |
分类号 |
A61K31/727;A61K31/737;A61P35/04;C08B37/00;C08B37/10;(IPC1-7):A61K31/725 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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地址 |
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