TAXOIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel taxoids of the general formula (I) <EMI ID=0.1 HE=37 WI=49 TI=CHI> where R means linear or branched alkyl radical with 1-6 carbon atoms; Z means hydrogen atom or radical of the general formula (II) <EMI ID=0.2 HE=20 WI=28 TI=CHI> where R1 means benzoyl radical or radical R2-O-CO- where R2 means alkyl radical with 1-8 carbon atoms; R3 means phenyl radical. New compounds of the general formula (I) where Z means radical of the general formula (II) show strong antitumor and antileukemic properties. Invention describes also the method of their synthesis and pharmaceutical composition based on said. EFFECT: improved method of synthesis, valuable antitumor activity. 7 cl