2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect

摘要

PCT No. PCT/EP97/00818 Sec. 371 Date Nov. 12, 1998 Sec. 102(e) Date Nov. 12, 1998 PCT Filed Feb. 20, 1997 PCT Pub. No. WO97/30982 PCT Pub. Date Aug. 28, 1997The invention concerns compounds of formula (I), in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R1, R2, R3 and R4 have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.