发明名称 |
Treatment of insulin resistance in obesity linked type II diabetes using antagonists to TNF- alpha function |
摘要 |
An induction of TNF- alpha mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF- alpha protein was also elevated locally and systemically. Neutralization of TNF- alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. A method of treating an animal suffering from insulin resistance in obesity linked Type II diabetes mellitus is disclosed. The method includes providing a therapeutic agent that includes an antagonist to TNF- alpha function in a pharmaceutically acceptable carrier substance and administering a pharmacologically effective amount of the therapeutic agent to the animal.
|
申请公布号 |
US6015558(A) |
申请公布日期 |
2000.01.18 |
申请号 |
US19980037777 |
申请日期 |
1998.03.10 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
HOTAMISLIGIL, GOEKHAN S.;SPIEGELMAN, BRUCE M. |
分类号 |
C12N15/09;A61K31/52;A61K31/522;A61K38/00;A61K38/17;A61K39/395;A61K45/00;A61K47/48;A61P3/08;A61P3/10;A61P43/00;C07K14/715;C07K16/00;C07K16/24;C07K16/28;C12P21/02;C12R1/91;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|