PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE TRANS-CYCLOHEXYLAMINE COMPOUNDS

摘要

A process for the preparation of optically active cyclohexylamine compounds useful as intermediates for the preparation of 1-phenyl-2-(3-phenylcyclohexyl-amino)ethanol compounds exhibiting a selective beta 3-adreneric receptor stimulating effect; N-substituted-3-phenylcyclohexylamine compounds as intermediates for the preparation; and 3-phenyl-2-cyclohexen-1-one compounds as raw materials therefor. The above process comprises conducting the reductive amination of a 3-phenyl-2-cyclohexen-1-one compound with an optically active amine compound through a Schiff base forming reaction and freeing the obtained product from the substituent on the nitrogen atom.