Pyrrolo [3,2-c] quinoline derivatives containing haloalkoxy group and pharmaceutically acceptable salts thereof

摘要

The present invention relates to a novel pyrrolo[3,2-c]quinoline derivatives containing haloalkoxy group, represented by Formula I, their pharmaceutically acceptable salts; process for preparation thereof; and pharmaceutical composition thereof for treating gastric ulcer. in which R1 is haloalkoxy group of C1-C6 including trifluoromethoxy, difluoromethoxy and trifluoroethoxy group. R2 and R3, which are the same or different, are each hydrogen, halogen, hydroxy, benzyloxy, alkyl group of C1-C6, alkoxy group of C1-C6. A is -CH2-CH2- or -CH=CH-, and R4 is hydrogen, halogen, amino, alkylamino group of C1-C6, and NH(CH2)nOH in which n is 1-6. Pyrrolo[3,2-c]quinoline derivatives having haloalkoxy group, and their pharmaceutically acceptable salts, which reversibly inhibit gastric acid secretion of mammal, are usefully utilized for gastric ulcer therapeutics.