发明名称 |
EXONS 4 AND 7 ENCODE SEPARATE TRANSACTIVATING AND CHROMATIN LOCALIZING DOMAINS IN ESX |
摘要 |
This invention identified two domains of ESX, a member of the ETS transcription regulator family, that provide particularly effective targets useful in screening for ESX modulators. One of these domains, ESX exon 4 is a potent transactivator and can be used in constructs to up-or downregulate genes or cDNAs, particularly genes or cDNAs under the control of a promoter containing an Ets element. Another of these domains, exon 7, is capable of acetylation and the level of acetylation can be used in assays for abnormal ESX regulation.
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申请公布号 |
CA2331266(A1) |
申请公布日期 |
1999.12.23 |
申请号 |
CA19992331266 |
申请日期 |
1999.06.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHANG, CHUAN-HSIUNG;SCOTT, GARY K.;BENZ, CHRISTOPHER C.;CHAO, YESU |
分类号 |
A61K38/00;C07K14/47;C07K14/82;C12Q1/68;G01N33/68;(IPC1-7):C07H21/04;C07K14/435;G01N33/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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