发明名称 |
NOVEL THERAPEUTIC AGENTS FOR MACROMOLECULAR STRUCTURES |
摘要 |
Disclosed are novel multibinding compounds (agents) which bind macromolecular structures including cellular, extracellular, and microbial components derived from vectors, viruses, fungi, yeasts, bacteria, and the like. The compounds of this invention comprise a plurality of ligands each of which can bind to such macromolecular structures thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker (framework) to provide for the multibinding compound. The linker is selected such that the multibinding compound so constructed demonstrates increased modulation or disruption of the biological processes/functions of cell as compared to the aggregate of the individual units of the ligand.
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申请公布号 |
WO9964036(A1) |
申请公布日期 |
1999.12.16 |
申请号 |
WO1999US11806 |
申请日期 |
1999.06.07 |
申请人 |
ADVANCED MEDICINE, INC.;GRIFFIN, JOHN, H.;MORAN, EDMUND, J.;OARE, DAVID |
发明人 |
GRIFFIN, JOHN, H.;MORAN, EDMUND, J.;OARE, DAVID |
分类号 |
C07K1/04;(IPC1-7):A61K38/00;A61K39/00;A61K39/44;A61K39/395;A61K51/00;C07K2/00;C07K4/00;G01N33/53;G01N33/543;G01N33/566 |
主分类号 |
C07K1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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