发明名称 |
Indicator reagents for assays using chemiluminescent electron-rich aryl substituted 1,2-dioxetanes |
摘要 |
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.
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申请公布号 |
US6001561(A) |
申请公布日期 |
1999.12.14 |
申请号 |
US19950437347 |
申请日期 |
1995.05.09 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
WANG, NAI-YI;HU, ROGER C. |
分类号 |
C07D321/00;C07D493/04;C07F7/18;C07F9/655;C07F9/6561;C12Q1/34;C12Q1/42;C12Q1/68;C12Q1/70;G01N33/533;G01N33/58;(IPC1-7):C09K3/00 |
主分类号 |
C07D321/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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