发明名称 |
PLATINUM COMPLEX, ITS PREPARATION AND THERAPEUTIC APPLICATION |
摘要 |
Disclosed is a platinum complex formula (I) wherein X represents a halogen atom, B represents, independently to each other, a halogen atom, a hydroxyl group or a carboxylate group containing 1 to 6 carbon atoms, and A represents a primary tricyclic amine containing 10 to 14 carbon atoms which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) each containing 1 to 4 carbon atoms, and, furthermore, an inclusion complex of the above platinum complex with beta- or gamma-cyclodextrin which may be optionally substituted by hydroxyalkyl groups containing 1 to 6 carbon atoms. There is also disclosed a process for the manufacture of the complex of formula (I) based on oxidation of a complex of divalent platinum of formula (II) with hydrogen peroxide and on optional substitution of hydroxyl groups in the obtained product with carboxylate groups by action of an acylating agent. The disclosed complexes may be used as such or as a part of pharmaceutical composition in a therapy of oncologic diseases.
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申请公布号 |
WO9961451(A1) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999CZ00015 |
申请日期 |
1999.05.24 |
申请人 |
LACHEMA, A.S.;ŽMISTR, ADOLF;POULOVA, ANNA;MĚTURANEK, JAROSLAV;ZALUSKA, DANA |
发明人 |
ŽMISTR, ADOLF;POULOVA, ANNA;MĚTURANEK, JAROSLAV;ZALUSKA, DANA |
分类号 |
A61P35/00;A61K31/28;A61K31/282;C07C211/38;C07F15/00;C08B37/16;(IPC1-7):C07F15/00 |
主分类号 |
A61P35/00 |
代理机构 |
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主权项 |
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地址 |
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