process for preparing oligonucleotides using product anchored sequential synthesis

摘要

A method of the solution phase synthesis of oligo-nucleotides comprises: a).reacting a 5'-protected monomer unit with a starting material (as defined in the specification) to form a reaction mixture containing an oligo-nucleotide product and b).partitioning the oligo-nucleotide product from the unreacted starting material, unreacted 5'-protected monomer unit, side-products and reagents based on the presence of the 5'-protecting group.