| 摘要 |
The invention relates to a composition comprising a phage or a functionally equivalent fragment thereof expressing at least one tumor-specific and/or tumor-associated antigen as fusion protein with a phage coat protein or a functionally equivalent derivative therefrom on its surface, and optionally, a pharmaceutically acceptable carrier and/or a pharmaceutically acceptable diluent. The invention also relates to a method for cloning and expressing tumor antigens on phages by means of which a specific immune response is induced. The invention further relates to a composition produced using said method, which is designed for use as injection preparation for specific immunotherapy of neoplasms in mammals and human beings. Examples of said neoplasms are haemoblastosis, preferably a malignant lymphoma, a urogenital carcinoma, preferably a kidney, bladder, prostate or testicular carcinoma, a gynecological carcinoma, preferably a mammary, ovarian, uterine or cervical carcinoma, a gastrointestinal carcinoma, preferably an esophagus, stomach, colon, rectum, pancreas, gall-bladder, cystic or hepatocellular carcinoma, a malignant endocrinological tumor, preferably a thyroid carcinoma, a malignant lung tumor, preferably a bronchiolar carcinoma or mesothelioma, a sarcoma or a CNS tumor.
|
