| 摘要 |
<p>A methyl ester of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine (A-form crystals) having characteristic X-ray diffraction peaks, e.g., at diffraction angles of at least 6.0°, 24.8°, 8.2°, and 16.5° (2υ, CuKα line) is dried to a water content below 3 wt.%. The thus-dried crystals are novel crystals (C-form crystals) of the methyl ester of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine which have an excellent rate of dissolution. These crystals, when examined by X-ray powder diffractometry, have characteristic X-ray diffraction peaks at least at diffraction angles of 7.1°, 19.8°, 17.3°, and 17.7° (2υ, CuKα line). When the C-form crystals are in the form of granules, they have further improved solubility.</p> |
