发明名称 |
INTRAMOLECULARLY-QUENCHED NEAR INFRARED FLUORESCENT PROBES |
摘要 |
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluoresence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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申请公布号 |
WO9958161(A1) |
申请公布日期 |
1999.11.18 |
申请号 |
WO1999US10589 |
申请日期 |
1999.05.13 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
WEISSLEDER, RALPH;TUNG, CHING-HSUAN;MAHMOOD, UMAR;JOSEPHSON, LEE;BOGDANOV, ALEXEI |
分类号 |
A61K49/00;C07K7/06;(IPC1-7):A61K49/00;G01N31/00;G01N33/48 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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