METHOD FOR PREPARING SULFANYL-TYPE ENDOTHELIN RECEPTOR ANTAGONISTS

摘要

The invention relates to a method for preparing sulfanyl-type endothelin receptor antagonists of general formula (I) wherein R<1> represents hydroxy, alkoxy, sulfonamidyl, amino; R<2> represents alkyl, aryl or heteroaryl, optionally substituted, and R<3>, R<4>, R<5> can be the same or different and are alkyl or aryl, optionally substituted, by means of nucleophilic reaction of a carboxylic acid derivative of formula (II) with a sulfide of formula (III), X being SR<6> or SO2R<6> and R<6> being alkyl or aryl, optionally substituted.