CARBAPENEM DERIVATIVES, UTILIZATION THEREOF AND INTERMEDIATE COMPOUNDS OF THE SAME

摘要

Carbapenem compounds represented by general formula (I) wherein R1 represent s a modifying group hydrolyzable in vivo; R2 and R3 may be the same or differe nt and each represents lower alkyl; and R represents a group represented by formula (B) or formula (C) (wherein R4 and R5 may be the same or different a nd each represents hydrogen or lower alkyl; and R6 represents C1-10 alkyl). Whe n administered orally, the compounds (I) are excellent in the absorbability vi a the digestive tract and exhibit sufficient antibacterial effects over a broa d scope of bacterial species. Thus, they are highly useful as preventives/remedies for infectious diseases, in particular, microbisms.