The ability to convert daunorubicin into doxorubicin can be improved by transforming a host cell with a recombinant vector comprising a DNA molecule comprising: a DNA region or fragment containing the gene doxA encoding daunorubicin 14-hydroxylase and a DNA region or fragment containing one or more gene conferring daunorubicin and doxorubicin resistance.
申请公布号
CA2326500(A1)
申请公布日期
1999.11.04
申请号
CA19992326500
申请日期
1999.04.22
申请人
PHARMACIA & UPJOHN S.P.A.
发明人
ZANUSO, GIOVANNA;OTTEN, SHAREE;COLOMBO, ANNA LUISA;HUTCHINSON, CHARLES R.;FILIPPINI, SILVIA;TORTI, FRANCESCA;SOLARI, AUGUSTO INVENTI