| 发明名称 |
RECOMBINANT ANTIBODY-TOXIN FUSION PROTEIN |
| 摘要 |
The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors. Construction and expression of a single chain antibody toxin fusion protein, anti-Tac(Pv)-PE40, gene and thereby the production of unproved toxins utilizing PE are described.
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| 申请公布号 |
CA2053911(C) |
申请公布日期 |
1999.11.02 |
| 申请号 |
CA19902053911 |
申请日期 |
1990.04.20 |
| 申请人 |
PROTEIN DESIGN LABORATORIES, INC.;THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, U.S. DEPARTM ENT OF COMMERCE |
发明人 |
PASTAN, IRA H.;FITZGERALD, DAVID;QUEEN, CARY L.;WALDMANN, THOMAS A.;CHAUDHARY, VIJAY K. |
| 分类号 |
A61K39/395;A61K38/00;A61K39/00;A61K47/48;A61P3/08;A61P29/00;A61P37/00;A61P37/08;C07K14/00;C07K14/195;C07K14/21;C07K14/41;C07K14/495;C07K14/55;C07K16/00;C07K16/28;C07K19/00;C12N1/21;C12N15/09;C12N15/62;C12P21/00;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):C12N15/62;A01N63/02;C12N15/13;C12N15/31 |
主分类号 |
A61K39/395 |
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