Fully integrated miniaturized planar liquid sample handling and analysis device

摘要

A miniaturized total analysis system (" mu -TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The mu -TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The mu -TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. mu -TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.