发明名称 |
Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset |
摘要 |
A delayed onset transdermal drug delivery device exhibiting a delay period of at least six hours comprising a laminated composite of (12) a top backing layer; (13) a pressure rupturable layer underlying (12); (14) a reservoir of a solution of drug in a liquid vehicle between (12) and (13); (16) a wick layer underlying (13) for dispersing the drug once (13( is ruptured; (17) a polymer layer underlying (16) that is permeable to the drug; (18) a microporous membrane underlying (17) which is itself impermeable to the drug but whose pores are filled with a polymer that is immiscible in the adhesive and has a solubility parameter within two units of the solubility parameter of the vehicle; and (20) an adhesive layer underlying (18) that is permeable to the drug but is immiscible in the polymer filling the pores of (6).
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申请公布号 |
US5273755(A) |
申请公布日期 |
1993.12.28 |
申请号 |
US19910748934 |
申请日期 |
1991.08.23 |
申请人 |
CYGNUS THERAPEUTIC SYSTEMS |
发明人 |
VENKTRAMA, SUBBU S.;FALLON, RENEE A.;CLEARY, GARY W. |
分类号 |
A61K9/70;(IPC1-7):A61F13/02 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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