发明名称 |
Process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl) methyl]pyridine a central nervous system agent |
摘要 |
An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes. |
申请公布号 |
ZA9507615(B) |
申请公布日期 |
1996.04.22 |
申请号 |
ZA19950007615 |
申请日期 |
1995.09.11 |
申请人 |
WARNER-LAMBERT COMPANY. |
发明人 |
DONALD EUGENE BUTLER;JODETTE GAILEY;TUNG VAN LE;WILLIAM JOHN SMITH III;DAVID JUERGEN WUSTROW |
分类号 |
C07C51/48;C07C51/487;C07C61/39;C07C62/38;C07C69/757;C07D211/70;C07D453/04 |
主分类号 |
C07C51/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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