| 发明名称 |
CRYSTALLIZATION PROCESS OF LOSARTAN POTASSIUM SALT |
| 摘要 |
<p>Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure. <IMAGE> This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.</p> |
| 申请公布号 |
CZ9901515(A3) |
申请公布日期 |
1999.10.13 |
| 申请号 |
CZ19990001515 |
申请日期 |
1997.10.24 |
| 申请人 |
MERCK AND CO. |
发明人 |
BREEN PATRICK;DIENEMANN ERIK A.;EPSTEIN ALBERT D.;LARSON KAREN A.;KENNEDY MICHAEL T.;MAHADEVAN HARI |
| 分类号 |
C07D403/10;(IPC1-7):C07D403/10 |
主分类号 |
C07D403/10 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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