发明名称 |
Monoclonal antibodies specific for the extracellular domain of prostate-specificmembrane antigen |
摘要 |
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection. |
申请公布号 |
AU3189699(A) |
申请公布日期 |
1999.10.11 |
申请号 |
AU19990031896 |
申请日期 |
1999.03.18 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
GERALD P. MURPHY;ALTON L. BOYNTON;ERIC H. HOLMES;WILLIAM THOMAS TINO |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P13/08;A61P35/00;C07K14/705;C07K16/28;C12N15/02;C12P21/08;C12Q1/26;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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