Heparin cofactor ii-containing compositions and method for stabilizing the same

摘要

Stable heparin cofactor II (HCII)-containing compositions. More particularly, HCII-containing compositions containing pH regulating agents as a stabilizer. These HCII-containing compositions are characterized by being adjusted to pH 6 to 12, preferably 6 to 10 and still preferably 6.5 to 10 by the pH regulating agent. HCII-containing compositions containing nonionic surfactant as a stabilizer. In these HCII-containing compositions, a decrease in HCII activity, polymerization of HCII and formation of insoluble matters are inhibited, thus achieving a high stability.