| 摘要 |
Under some conditions which normally induce cell death, the addition of amino acid degrading enzymes protect cells from death. Under other conditions, such as TNF alpha exposure, amino acid degrading enzymes potentiate TNF alpha -induced cell death. Both of these amino acid degrading enzyme actions may result from inhibition of protein synthesis. Screening can identify compounds that affect the amino acid degrading enzyme-mediated protection. These compounds, as well as the amino acid degrading enzymes themselves, may be used for the treatment of diseases associated with cell death. In addition, amino acid degrading enzymes may be used in conjunction with TNF alpha to increase cancer cell death. |
