发明名称 |
Hla linked pre-eclampsia and miscarriage susceptibility gene |
摘要 |
The invention relates to the identification of a susceptibility gene for pre-eclampsia and eclampsia and provides methods and diagnostic kits for diagnosing susceptibility to normal pregnancy, pre-eclampsia, eclampsia, intrauterine growth retardation, miscarriage or miscarriage-related infertility. The invention is based on analysing HLA-G or HLA-G linked nucleic acid, or HLA-G protein or HLA-G mRNA or cells or molecules whose concentration changes as a result of HLA-G action. The invention also provides pharmaceutical compositions for and methods of treatment of the above conditions. |
申请公布号 |
AU2636399(A) |
申请公布日期 |
1999.09.15 |
申请号 |
AU19990026363 |
申请日期 |
1999.02.25 |
申请人 |
NATIONAL UNIVERSITY OF IRELAND, CORK |
发明人 |
MARGARET O'BRIEN;JOHN BERMINGHAM;KATHLEEN A. QUANE;DAVID M. JENKINS;TOMMIE V. MCCARTHY |
分类号 |
A61K35/14;A61K38/00;A61K39/395;A61K45/00;A61P15/00;A61P15/06;A61P15/08;C12N5/10;C12N15/09;C12N15/12;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/564;G01N33/569;G01N33/68 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|