| 发明名称 |
Therapeutic compound-fatty acid conjugates |
| 摘要 |
PCT No. PCT/AU96/00015 Sec. 371 Date Sep. 25, 1997 Sec. 102(e) Date Sep. 25, 1997 PCT Filed Jan. 15, 1996 PCT Pub. No. WO96/22303 PCT Pub. Date Jul. 25, 1996A methotrexate conjugated to 1-3 acyl groups derived from fatty acids. In particular the invention relates to altering the pharmacokinetic profile and mode of delivery of methotrexate by conjugating it to 1.2 or 3 acyl derivatives of fatty acids.
|
| 申请公布号 |
US5952499(A) |
申请公布日期 |
1999.09.14 |
| 申请号 |
US19970875098 |
申请日期 |
1997.09.25 |
| 申请人 |
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION |
发明人 |
WHITTAKER, ROBERT GEORGE;BENDER, VERONIKA JUDITH;REILLY, WAYNE GERRARD;MOGHADDAM, MINOO |
| 分类号 |
C07K14/775;A61K31/57;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61K38/00;A61K38/05;A61K47/48;A61P25/04;A61P29/00;A61P31/12;A61P37/04;C07C237/22;C07D475/08;C07D489/02;C07H19/04;C07H19/06;C07J5/00;C07J41/00;C07K5/00;C07K5/065;C07K7/06;(IPC1-7):A61K31/495;A61K31/505;C07D475/00 |
主分类号 |
C07K14/775 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
