Photostable aqueous solution containing benzyl alcohol derivatives

摘要

PCT No. PCT/JP96/01950 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05860 PCT Pub. Date Feb. 20, 1997Aqueous solution, including at least one of optically active (-)-(R)- alpha -((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol represented by the following formula: and pharmacologically acceptable salt thereof. The aqueous solution also includes at least one photostabilizer selected from the group consisting of saccharide, sugar alcohol, and polyalcohol. A content of the at least one of optically active (-)-(R)- alpha -((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof is 0.01 to 10% (w/v) based on a volume of the aqueous solution. A content of the at least one photostabilizer is 1 to 50% (w/v) based on the volume of the aqueous solution. The content of the at least one photostabilizer is at least 10% (w/w) based on a total weight of the at least one of optically active (-)-(R)- alpha -((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof. Method of making a stabilized aqueous solution.