| 发明名称 |
INDENO[1,2-e]PYRAZINE-4-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME |
| 摘要 |
<p>PCT No. PCT/FR95/00357 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26349 PCT Pub. Date Oct. 5, 1995The compounds of formula (I) <IMAGE> (I) wherein R, R1 and R2 are defined in the disclosure, and salts thereof. The compounds of formula (I) are non-competitive N-methyl-D-asparate (NMDA) receptor antagonists, particularly NMDA receptor glycine modulation site ligands, and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, this receptor is also known as the quisqualate receptor.</p> |
| 申请公布号 |
GR3030273(T3) |
申请公布日期 |
1999.08.31 |
| 申请号 |
GR19980402937T |
申请日期 |
1999.05.27 |
| 申请人 |
RHONE-POULENC RORER S.A. |
发明人 |
ALOUP, JEAN-CLAUDE;AUDIAU, FRANCOIS;BARREAU, MICHEL;DAMOUR, DOMINIQUE;GENEVOIS-BORELLA, ARIELLE;JIMONET, PATRICK;MIGNANI, SERGE;RIBEILL, YVES |
| 分类号 |
A61K31/495;A61P1/08;A61P1/16;A61P3/04;A61P9/00;A61P9/08;A61P9/10;A61P25/00;A61P25/28;A61P29/00;A61P31/12;A61P37/04;A61P39/02;C07D405/04;C07D409/04;C07D487/04;C07D487/14;C07D491/147;C07D495/14;(IPC1-7):C07D487/04;C07D471/14 |
主分类号 |
A61K31/495 |
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