| 摘要 |
<p>PROBLEM TO BE SOLVED: To profitably obtain the subject compound whose amino group is protected with a protecting group for protecting the amino group from its self condensation and which is useful as an intermediate for producing medicine by reacting a specific aminothiazole acetic acid ester derivative with a chloroacetylation agent in the presence of a specific acid-capturing agent. SOLUTION: (A) An aminothiazol acetic acid ester derivative of formula I (X is an alkyl or the like; Y is two H or the like) [for example, 2-(2- aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid ethyl ester] is reacted with (B) a chloroacetylation agent (for example, chloroacetyl chloride) in the presence of (C) an acid-capturing agent for capturing an acid by an addition reaction (for example, propylene oxide) preferably at -30 to 80 deg.C usually for 0.1-100 hr to obtain the objective compound of formula II [for example, 2- chloroacetylaminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid ethyl ester].</p> |
