发明名称 |
Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob |
摘要 |
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is achieved. This recombinant adenovirus has a fiber gene modified in the HI loop domain. |
申请公布号 |
AU2659599(A) |
申请公布日期 |
1999.08.23 |
申请号 |
AU19990026595 |
申请日期 |
1999.02.05 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
DAVID T CURIEL;VICTOR N. KRASNYKH;IGOR DMITRIEV |
分类号 |
C12N15/09;A61K48/00;A61P37/02;A61P43/00;C07K14/075;C12N7/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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