| 摘要 |
<p>The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceotor in the presence of an acid catalyst, the α and β isomers of GM3 are formed. The α isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the β isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.</p> |
