PEPTIDE MIMOTOPES OF CARBOHYDRATE ANTIGENS

摘要

Methods of preparing a peptide and antigenic antibodies which mimic an antigenic carboyhdrate are disclosed. The method comprises the steps of identifying a peptide sequence which is immunogenically cross reactive an antigenic carbohydrate and synthesizing a peptide or recombinant antibody which comprises the peptide sequence. Methods of generating an immune response against a pathogen or tumor cell in an individual using such peptides, recombinant antibodies comprising such peptide, or DNA vaccines live attenuated vaccines, or recombinant vaccines that encode such peptides are disclosed. Methods of enhancing binding of anti-antigenic carbohydrate antibodies to the antigenic carbohydrate in an individual are disclosed. The methods comprise administering to an individual anti-antigenic carbohydrate antibodies and a peptide which mimics the antigenic carbohydrate. Methods of inhibiting binding of a ligand to a receptor which is an antigenic carbohydrate are disclosed. The methods comprise administering to an individual a peptide which mimics an antigenic carbohydrate. Methods of identifying peptide sequences which can induce an immune response against two or more different pathogens are disclosed. Novel compositions are disclosed.