发明名称 |
Interaction of MHC Class II proteins with members of the PCNA family of proteins |
摘要 |
Present invention based on the identification of the molecular interaction that forms the basis of the immunosuppressive activity of peptides comprising residues 71-80 of an MHC Class II protein (Class II peptides). Specifically the present invention discloses that Class II peptides bind to members of the PCNA family of proteins. Based on this observation, present invention provides methods for identifying agents that can be used to modulate immune system activity.
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申请公布号 |
US5935797(A) |
申请公布日期 |
1999.08.10 |
申请号 |
US19970829132 |
申请日期 |
1997.03.28 |
申请人 |
STANFORD UNIVERSITY |
发明人 |
CLAYBERGER, CAROL;KRENSKY, ALAN M. |
分类号 |
C07K14/47;C07K14/74;(IPC1-7):G01N33/53 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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